Publications

Since 2010. Please visit ncbi.nlm.nih.gov to access John M. Hawdon's full bibliography

2021

Motaher R, Grill E, McKean E, Kenney E, Eleftherianos I, Hawdon JM, O'Halloran DM. Chemogenomic approach to identifying nematode chemoreceptor drug targets in the entomopathogenic nematode Heterorhabditis bacteriophora. Comput Biol Chem 2021 Feb 24; 92:107464. Epub ahead of print. PMID: 33667976.

Kenney E, Hawdon JM, O'Halloran DM, Eleftherianos I. Secreted virulence factors from Heterorhabditis bacteriophora highlight its utility as a model parasite among Clade V nematodes. Int J Parasitol 2021 S0020-7519(20)30336-2. Epub ahead of print. PMID: 33421438.

2020

Langeland A, Hawdon JM, O'Halloran DM. NemChR-DB: a database of parasitic  nematode chemosensory G-protein coupled receptors. Int J Parasitol 2020 1:S0020-7519(20)30314-3. Epub ahead of print. PMID: 33275943.

Bernot JP, Rudy G, Erickson PT, Ratnappan R, Haile M, Rosa BA, Mitreva M, O'Halloran DM,* Hawdon JM*. Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism. Int J Parasitol 2020 50(8):603-610. PMID: 32592811. *co-senior authors

Kenney E, Yaparla A, Hawdon JM, O'Halloran DM, Grayfer L, Eleftherianos I. A putative UDP-glycosyltransferase from Heterorhabditis bacteriophora suppresses antimicrobial peptide gene expression and factors related to ecdysone signaling. Sci Reports 2020 10(1):12312. PMID: 32704134; PMCID: PMC7378173.

Kenney E, Yaparla A, Hawdon JM, O' Halloran DM, Grayfer L, Eleftherianos I. A putative
lysozyme and serine carboxypeptidase from Heterorhabditis bacteriophora show differential virulence capacities in Drosophila melanogaster. Dev Comp Immunol 2020 114:103820. PMID: 32791175.

2019

International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms. Nature Genetics 2019 51:163-174. PMID: 30397333.

Kitchen S, Ratnappan R, Han S, Leasure C, Grill E, Iqbal Z, Granger O, O'Halloran DM, Hawdon JM.  Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum. International Journal for Parasitology 2019 49(5):397-406. PMID: 30771359; PMCID: PMC6456372.

Kenney E, Hawdon JM, O'Halloran D, Eleftherianos I. Heterorhabditis bacteriophora excreted-secreted products enable infection by Photorhabdus luminescens through suppression of the Imd pathway. Frontiers in Immunology 2019 10:2372. PMID:31636642; PMCID: PMC6787769

2018

Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open Forum Infect Dis2018 May;5(5):ofy083.  PMID: 29780848; PMCID: PMC5952933.

Magrini V, Gao X, Rosa BA, McGrath S, Zhang X, Hallsworth-Pepin K, Martin J, Hawdon JM, Wilson RK, Mitreva M. Improving eukaryotic genome annotation using single molecule mRNA sequencing.
BMC Genomics. 2018 Mar 01;19(1):172.

Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF. Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing. Sci Reports. 2018 Jan 17;8(1):975.

2017

Feather CM, Hawdon JM, March JC. Ancylostoma ceylanicum infective third-stage larvae are activated by co-culture with HT-29-MTX intestinal epithelial cells. Parasit Vectors. 2017 Dec 15;10(1):606.

Vadnal, J, Ratnappan, R, Keaney, M, Kenney, E, Eleftherianos, I, O’Halloran, D, Hawdon, JM.
Identification of candidate infection genes from the model entomopathogenic nematode Heterorhabditis bacteriophora. BMC Genomics. 2017 Jan 3;18(1):8.

2016

Weeks, JC, Roberts, WM, Robinson, KJ, Keaney, M, Vermeire, JJ, Urban,JF Jr., Lockery, SR, Hawdon, JM. Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):314-328.

Hawdon JM. Acceptance of the 2016 Henry Baldwin Ward Medal – a long and winding road to a Diet of Worms.J Parasitol. 2016 Dec;102(6):579-586.

Cook, JA, Greiman, SE, Agosta, SJ, Anderson, RP, Arbogast, BS, Baker, RJ, Boeger, W, Bradley, RD, Brooks, DR, Cole, R, Demboski, JR, Dobson, AP, Dunnum, JL, Eckerlin, RP, Esselstyn, J, Galbreath, KE, Hawdon, J, Hoekstra, HE, Kutz, SJ, Light, JE, Olson, LE, Patterson, BD, Patton, JL, Phillips, AJ, Rickart, E, Rogers, DS, Siddall, ME, Tkach, VV, Hoberg, EP.
Transformational Principles for NEON Sampling of Mammalian Parasites and Pathogens: A Response to Springer and Colleagues.
BioScience. 2016 Nov 1;66(11): 917-919.

Ratnappan R, Vadnal J, Keaney M, Eleftherianos I, O'Halloran D, Hawdon JM. RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora.
Parasit Vectors. 2016 Mar 18;9(1):160.

2015

Gelmedin V, Delaney A, Jennelle L, Hawdon JM. Expression profile of heat shock response factors during hookworm larval activation and parasitic development. Mol Biochem Parasitol. 2015 Jul;202(1):1-14.

Gao  X, Goggin  K, Dowling  C, Qian  J, Hawdon JM. Two potential hookworm DAF-16 target genes, SNR-3 and LPP-1: gene structure, expression profile, and implications of a cis -regulatory element in the regulation of gene expression. Parasit Vectors. 2015 Jan; 8:14

2014

Hawdon JM. Controlling soil-transmitted helminths: time to think inside the box? J Parasitol. 2014 Apr;100(2):166-88. Review.

Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RK, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M. Genome of the human hookworm Necator americanus.
Nat Genet. 2014 Mar;46(3):261-9.

2012

Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE.
Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.
J Biol Chem. 2012 Feb10;287(7):4894-903.

2011

Dryanovski DI, Dowling C, Gelmedin V, Hawdon JM. RNA and protein synthesis is required for Ancylostoma caninum larval activation. Vet Parasitol. 2011 Jun30;179(1-3):137-43.

Krepp J, Gelmedin V, Hawdon JM. Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation. Int J Parasitol.2011 Apr;41(5):533-43.

Gelmedin V, Brodigan T, Gao X, Krause M, Wang Z, Hawdon JM. Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer. PLoS One. 2011;6(10):e25996.

2010

Weaver HJ, Hawdon JM, Hoberg EP. Soil-transmitted helminthiases: implications of climate change and human behavior. Trends Parasitol. 2010 Dec;26(12):574-81.

Gao X, Wang Z, Martin J, Abubucker S, Zhang X, Mitreva M, Hawdon JM. Identification of hookworm DAF-16/FOXO response elements and direct gene targets. PLoS One. 2010 Aug 19;5(8):e12289.

Wang Z, Abubucker S, Martin J, Wilson RK, Hawdon J, Mitreva M.
Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.
BMC Genomics. 2010 May 14;11:307.